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KMID : 0363320150360030284
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Journal of Korean Oriental Internal Medicine
2015 Volume.36 No. 3 p.284 ~ p.296
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Effect of Ohmae-hwan and Mume Fructus on DSS-Induced Inflammatory Bowel Dise v vvgase in a Mice Model System
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Kim Eui-Su
Shin Min-Gu
Kim Tae-Ryun
Shin Man-Ho
Lee Young-Soo
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Abstract
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Objectives: The purpose of this study was to examine the effects of Ohmae-hwan (OMH) and Mume Fructus (MF) on inflammatory bowel disease (IBD).
Methods: Mice were divided into 4 groups: a normal group, control group, MF group, and OMH group. Three groups, excluding the normal group, were fed a 5% solution of dextran sulfate sodium (DSS) in water for 10 days to induce inflammatory bowel disease. From the fourth day of DSS treatment, the control group was given distilled water only, the MF group was given MF powder in distilled water, and the OMH group was given dried OMH extract powder in distilled water for 7 days.
Results: For each animal, changes in body weight, colon length, and component levels in blood and colon tissues after each treatment were noted. The weight in the control group and MF group decreased slightly compared with that in the OMH group, and the colon length in the MF group and OMH group was more than that in the control group. TNF-α and WBC were decreased in both the MF group and the OMH group. RBC was increased in the OMH group, like in the normal group, compared with the control group and MF group. Hb and PLT of each group were not significantly different. Regarding changes in the colon tissues, both the MF group and OMH groups recovered similar to the normal group.
Conclusions: Thus, treatment with OMH and MF seems to be effective against inflammatory bowel disease, and OMH is likely to increase body weight and induce RBC recovery better than MF.
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KEYWORD
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inflammatory bowel disease, colitis, DSS, Mume Fructu
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